The growth of internet gambling and the implications for regulation Essay

The growth of internet gambling and the implications for regulation and harm minimisation in Australia - Essay Example Based on the discussion and analysis, it has been analyzed that Australia has become one the major countries in online gambling industry. The economic benefits which gambling industry has been providing to Australia stopped the government to pursue the effective harm minimisation programs. Today, online gambling has increased the concerns for Australian regulators because of the increasing problem gambling, crime rate etc. Even the harm minimisation programs have been unsuccessful to curb the growth of increasing internet gambling. It can be projected based on the current growth of internet gambling that soon gambling will become the largest industry of Australia and concerns will further increase. If Australian government pursues stricter legislative framework and other strategies to stop the growth of internet gambling, it forgoes the huge economic benefits. If Australian government keeps pursuing the current strategies then current growth will keep its pace. On the other hand, if Australian government introduces more flexible policies, then economic issues can increase however, the government can enjoy huge influx of revenues. Therefore, in which direction Australian government should go, completely depends on the long-term economic strategies of the government. However, one important thing which this research essay has highlighted is that growing online gambling does have significant implications for Australian government and harm minimisation. In the beginning, all original forms of gambling were prohibited however, gradually all of them were legalised. The online gambling started in Australia in 1996 in the Northern Territory and in 2001, when the federal government legalised internet gambling, Interactive Gambling Act 2001 was introduced. (Hsu, 2006). Since then gambling industry of Australia is expanding and growing very rapidly and it has even created a lot of challenges for the Australian economy. What Australian Government has been Doing to Control O nline Gambling in Past? Internet gambling has established new challenges for the regulators because unlike traditional casinos, the online gambling websites cannot be closed (Schwarz, 1999). Therefore, because of the nature of online gambling, it could be only controlled through government regulations. Even after legalising gambling, Australian Government has always remained concerned to monitor and control online and traditional gambling. The Australian Government has taken the regulatory responsibility of online gaming and according to Interactive Gambling Act 2001, government has made domicile online gaming site illegal for the Australian residents and these websites only target the oversees community. However, despite the control through regulations and legislations, Australian Government is facing problems in control the internet gambling market in Australia (Fabiansson, 2010). Australian Gambling Regulation controls gambling in Australia. With the growing online gambling, Aust ralian Government introduced Australian Interactive Gambling Act (IGA) 2001 which bans online gambling in Australia. According to this Act, offering interactive gambling service to an individual physically present in Australia is an offense. If a person commits this offence, he is subject to a penalty of $220,000 per day if he offers services to individuals and penalty of $1.1 million per day if he serves corporate bodies. Moreover, online wagering and lotteries are not prohibited (Humphrey, 2008). The online gambling costs are increasing and to minimise harm from gambling activities, harm minimisation strategies are in place. To achieve harm minimisation, Australian Government has adopted three strategies; first, through direct regulation of internet gambling sites; second, covering online gambling within the broader gambling regulation framework; third, achieving harm minimisation through non-regulatory approaches (FAHCSIA, 2009). Growth in Online Gambling in Australia The Austral ian economy realised the growing trends in traditional and internet gambling with the increase in household spending on gambling. With the expansion of gambling in Australia, the proportion of money spent on gambling per household also increased from 1.7 percent in 1982-1983 to 3.2 percent in 1997-1998 (Australian Bureau of Statistics, 2000). In 2002-2003, around Australian $18.54 million were spent on internet gambling in Austr

The Intelligence and Aging of People Essay Example | Topics and Well Written Essays - 500 words

The Intelligence and Aging of People - Essay Example Depending on the definition of the term intelligence, it can either be decreasing with age (when defined as unitary property), or it can be increasing with age (when defined as an entity consisting of multiple factors) (Merriam, Caffarella, and Baumgartner, 2007). There are many studies that prove that fact that ageing does not necessarily mean a reduction of intelligence. In one of the researches, the authors present their findings based on various tests which help to analyze long and short-term memory tasks of older adults ageing (ages 60 through 80) and younger adults (ages 18 through 30) (Bartlett, 2002). The aim of the research was to analyze how ageing and experience might affect different aspects of cognition. This research was conducted on the basis of a variety of tasks. It was found that there was little to no age effect. Moreover, it was concluded that both adult and young participants of the study equally benefited from the â€Å"usefulness of domain-specific musical knowledge† (Barlett, 2002, p. 18). Interesting, ageing was in many tasks considered more beneficial than experience. Finally, the researchers found that there were no relationships between ageing and music cognition skills; besides, they never found that age differences were reduced in persons who had had more years of musical practice. The research based on musical expe rience may be transferred to other domains of cognition. Thus, it could be concluded that ageing should not be viewed as some negative process of adulthood, but rather as the ability to get to a bank of cognition resources.

Quality Insurance Research Paper Example | Topics and Well Written Essays - 2250 words

Quality Insurance - Research Paper Example Loading of the testing software†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.†¦Ã¢â‚¬ ¦7 c. The data to be in use†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦..7 d. The specific systems to be in use†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.7 e. Test environment†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦8 VII. Description of techniques that should be employed†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦8 VIII. Description of the tools that should be used to conduct the tests†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦9 IX. Summary of how defects will be documented and how they will be resolved...9 X. Requirements traceability mapping†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã ¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦9 XI. List of testing roles, responsibilities, and timeline†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦10 XII. Conclusion†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦10 XIII. References†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.12 Introduction Quality insurance is the process of testing the functionality, effectiveness, and detection of any defects of a computer software. The quality insurance is extremely essential for the attainment of an effective project. Thus before the project applied, it ought to undergo through testing. The document explains the measures and procedures that the software tools should follow to perform its fu nctions effectively, for instance the function of copying and also the imaging of the hard disk drives. The software is for the forensic investigation procedure when retrieving data from the hard disk drive in a computer. The software tool is called forensic software testing support tools (FS- TST). This is software that aids in testing the hard disk imaging tools during forensic investigation (Gavrila & Fong, 2004). Overview of the Document Content The following is a test plan for the project on the development of hard disk drive. The document contains a summary of the quality insurance objectives as well as the quality metrics that will be in application in this project. The document also tackles the summary on the areas of the application that will be undergoing testing. There is also the documentation of brief description of the artifacts that will be in use during the testing process. Some of the artifacts include load testing software, specific systems, test cases, and the dat a to be in use. There is also the description of the techniques that is in use during the testing process. The document further contains the description of the tools that ought to be in use during the conduction of the testing process. Furthermore, there is a brief summary of how the defects will be put in documentation and the resolution of these defects. The document also contains the requirements traceability that shows how this test validates and further verifies these functional requirements. Finally, the document provides a list of roles of the testing as well as the responsibilities and the tests timelines (Gavrila & Fong, 2004). Quality Objectives for the Application and Quality Metrics The quality objective for the application of the quality metrics on the hard disk drive is extremely important. The following test plan for the software of forensic software testing support tools, FS-TST, has to fulfill the objective of detailing the main activities that is necessary for the preparation and for conducting the testing of the FS-TST. Another

There is no set topic Research Paper Example | Topics and Well Written Essays - 1000 words

There is no set topic - Research Paper Example The poem has four stanzas, each of eight lines, which follow a rhyming scheme of abababcd. There are many imageries employed in the poem as the poet compares his old being with â€Å"a paltry thing† and â€Å"A tattered coat upon a stick†. According to the poet, he is an old creature who has no value and is like a torn coat hanging on a stick. His existence is all ragged because of the long time that he has passed in this world but Byzantium is full of youth and inspires him with its youthfulness. He further elaborates his situation and says, According to Yeats, his soul is â€Å"fastened to a dying animal† and that is his body. He describes that he is old and his body is no more young, however, his soul is youthful and is â€Å"sick with desire†. According to Rukhaya (2010), â€Å"It now seems like an alien to himself incompatible with his aged body†. His body is alien to him, as he wants to get rid of it because of his youthful soul. Yeats shows infatuation with the idea of gold and gold creations as he mentions gold a number of times in the poem as he uses the words, â€Å"gold mosaic†, â€Å"hammered gold†, â€Å"gold enamelling† and â€Å"golden bough†. Yeats uses a number of symbols in â€Å"Sailing to Byzantium† such as â€Å"Byzantium† (Holy City), â€Å"dying animal† (old man), â€Å"mortal dress† (human body) and gold made bird by â€Å"Grecian goldsmiths. Franke (1998) says, â€Å"One of the most powerful and richly poetic of all Yeats’ unifying symbols is the Sacred City of Byzantium† (25).Byzantium that is used as a holy land by Yeats is itself a poetic symbol employed by him. The word, â€Å"Byzantium† stands for ancient art and what is manmade. Yeats shows inspiration for Byzantium because of its association with Greek world and artistic vigor found in the land. Byzantium is depicted as an eternal land. The poem Sailing to Byzantium by W.B. Yeats,

Globalization and International Sweatshops Essay Example for Free

Globalization and International Sweatshops Essay Firstly, globalization is good to the extent that it respects each country’s security needs, while at the same time discouraging states which threaten or are likely to threaten global peace. When states are interdependent, despotic leaderships appreciate that jeopardizing global security puts them at the rsik of losing trade connections with other states. Secondly, globalization is good if and when it allows each country to use its economic advantage to compete. States are endowed differently and some are more developed than others. As such, it is important that every state should have the room to use its economic advantage to improve its economy. Lastly, globalization must encourage internationally-acceptable labour practices. Although developing countries may not have identical labour standards as the developed countries, the former must show deliberate effort to improve their labour standards (Reich, n. d). Ciulla would differ sharply with Maitland’s defense of international sweatshops. It is a fact that everybody, including the poorest people in the least developed and badly-governed states have the right to choose their work (Cuilla, n. d). However, this practical range of choice is so narrow that they have no alternative but to work for the sweatshops, inspite of the poor pay and terrible working conditions. Widespread unemployment in the Third World, which compels thousands of the residents to seek employment opportunities in the sweatshops, does not give the latter the right to exploit, abuse the workers or to pay them poorly. Many of the multi-national sweatshops operate branches in the developed world and the developing world. While their workers in the former are paid well and enjoy better employment terms, the workers in the developing world are paid very poorly, yet they are mostly assigned physically-demanding, dirty and dangerous parts of the production process. By employing underage persons, these sweatshops break national and international law. Their influence however means that the host governments turn a blind eye to their malpractices. References Ciulla, The Working Life. Maitland, I. (n. d). In Defense of International Sweatshops. Reich, R. (n. d). Escape from the Global Sweatshop.

Sample of Campus News Paper Essay Example for Free

Sample of Campus News Paper Essay As Christians, one the biggest struggles we face is putting our complete trust in God. We find this challenging because as human beings, we continually let one other down. When people in our lives hurt, disappoint or betray us, it becomes more difficult to trust in their love. As a result, we start believing that God will let us down also. We must remember one important thing. God is not a human being. He is a spiritual who will never fail or forsake his children. He is always there to love, listen, and comfort us. In all circumstances and stages of life, wherever we may be, whether good or bad, God is there for us. When we place our wholehearted faith into his hands, God will always encourage and provide us with everything that we could possibly need or desire. We should never be afraid to call on God or to trust in His love for us. If we place our trust in Christ, we will begin to live life more fully and heighten our spiritual growth in the Lord. God has a unique plan and purpose for each one of us. We should not be afraid to trust his guidance. For only God knows what is best for us. God loves all those who believe in Him. In addition, He will lead us down the right path if we are willing to trust His guidance. In all of life’s struggles and challenging situations, there is nothing that God cannot handle. For humans living in the modern technological world, we tend to prefer quick solutions to problems, immediate results and instant gratification. As a result, we find it particularly challenging to completely trusting God with our daily cares and concerns. We may be discouraged when God doesn’t provide us with exactly what we asked for and when we need it. God’s spiritual timing is much different than ours. At times, it may seem like he is unfaithful or doesn’t care about our needs. Bun in fact, the opposite is true. He wants to ensure that we are ready for the necessary life changes and adjustments which need to be made. God never gives us more that we can handle. He wants us to live our lives in accordance with His ways. Traveling down God’s spiritual path can be scary and even risky at times, but the rewards of life’s journey through faith are even greater. Together through daily prayer, meditation, and sharing of God’s faith with others, we can grow more fully in our walk with Christ. So let us take that leap of faith by trusting in God’s protection and care in our life, each and every day. Once we do, our life will never be the same. In fact, we might be amazed at what God has planned for us.

Carbonic Anhydrase The Fastest Enzyme Biology Essay

Carbonic Anhydrase The Fastest Enzyme Biology Essay Carbonic anhydrase, abbreviated as CA, is the first identified zinc containing enzyme, (CA; carbonate hydro-lyase, EC 4.2.1.1) It is an enzyme that catalyzes the reversible hydration and dehydration of carbon dioxide to form carbonic acid, bicarbonate ions and protons. Being one of the fastest enzyme known, it is believed that one molecule of CA can process one million molecules of carbon dioxide  per second. The basic molecular structure of CA includes specific amino acid threonine 199, glutamate 106, histidine 64 and histidine residues namely His 93, His 95, and His 118. The mode of regulation of CA is being inhibited by various medically prescribed substances that act as non competitive inhibitors, an example is Acetazolamide. CA plays a major key role in the fluid balance and regulatory of pH in different parts of the body thus, Mutation of this enzyme may lead to several diseases.(1) CARBONIC ANYHYDRASE THE START: Breathing, a fundamental function in life The air that we breathe in has some valuable oxygen, an important molecule wherein it helps the breakdown of fats and sugars in our cells. From the blood, oxygen diffuses then binds with the hemoglobin to be transported in the cells of our body. A by product of sugar and fat breakdown in cells is called Carbon dioxide CO2). It is a key metabolite in all living organism and it needs to be removed from our body. Carbon dioxide is diffuse out of the cells and transported in the blood in different ways to get to the lungs. CA is transported in numerous forms, mainly as bicarbonate, HCO3-. Bicarbonate is a CO2- with an attached OH group. When the HCO3- reaches the lungs, it is transformed back to a CO2, so it can be exhaled from the body. The conversion of bicarbonate to carbon dioxide facilitates its transport into the cell; while the conversion of carbon dioxide to bicarbonate assists trap the carbon dioxide in the cell. This interconversion of carbon dioxide and bicarbonate develop at a slow physiological pH hence organism tend to produces an enzyme to hasten the process. This enzyme responsible for the speed up interconversion, which can be found in the red blood cells, is called carbonic anhydrase. Although the interconversion of bicarbonate to carbon dioxide can happen without the enzyme, CA can great increase the rate of the conversions up to a millions of fold. (2) STRUCTURE The CA molecule in general has ellipsoidal shape with the estimated dimension 4.1 x 4.1 x 4.7 nm. The active site is situated in a cavity having an approximately conical shape. The cavity is assessed 1.5 m wide at the way in and about 1.6 nm deep attaining almost the center of the molecule. The zinc ion is next to the peak of the cone and liganded into 3 imidazole groups. Figure 1. CA Structure (2) Figure 1. shows the structure of CA. Taken as a whole, is composed of 10-stranded anti-parallel beta-sheet enclosed with various elements of other secondary structure. The 6 alpha-helices and 10-beta sheets make up the secondary structure of carbonic anhydrase. The basic function of CA is basically to regulate the oxygen and carbon dioxide content of the blood that is needed in a human body. As the function suggests, the chemical structure of CA extremely lies with the presence of zinc that lies deep within its active site. Its common amino acid composition includes threonine, glutamate and histidine. The specificity of these 3 amino acids (threonine 199, glutamate 106, and histidine 64) plays a critical role in relation to the presence of zinc by charging it with a hydroxyl ion. The zinc cation is associated with three histidine residue protein backbone namely: His93, His95, and His118. As stated, zinc plays a major role in the reaction of CA. The zinc present in the active side of CA is being bound to water to be able to dissociate it into a proton and hydroxyl ion. The hydroxyl ion is being stabilized by the positively charged zinc, in this way; the hydroxyl ion is being prepared to attack the carbon dioxide inside the RBC. A closer look with CA can be seen in the figure below where the amino acid chains in the active site together with the zinc are evident. The role of the zinc basically includes the command of directional transfer of the bound hydroxyl to the carbon dioxide to be able to form bicarbonate ion. From the figure, it shows that the intermediate structure where the bicarbonate ion is still attached to the enzyme. The alanine replicated the side chain for amino acid 199 in this arrangement. Histidine 64 swings in the direction of and away from the zinc ion in every cycle of enzyme action although it is helping the zinc to recharge with a novel hydroxyl ion. The two locations of this residue, revealed in the bottom right figure, symbolize its movement throughout the action of enzyme. Almost immediately as the zinc is reloaded with an original water molecule together with the release of bicarbonate ion, the enzyme is set for another action on some new carbon dioxide molecule. (3) MECHANISM OF CATALYSIS The rate of catalysis of the CA is exceedingly pH dependent. It means that, the higher the pH, the catalysis is faster and as the pH reduces, the speed of the reaction falls down. The mean pH of this transition is near pH 7. (5) Figure 2. Mechanism of CA catalysis (6) Figure 2.0 shows the mechanism of CA catalysis. A zinc atom which is generally bound to four or more ligands differs in CA. In CA, three locations are occupied by imidazole ring of three histidine residues and an additional site is occupied by a water molecule. Thus the geometry form of the active site is tetrahedral. The zinc atom plays an important role in the mechanism of CA catalysis because it is responsible for the release of a proton H+ from a water molecule, which then generates a nucleophilic hydroxide ion. Then the carbon dioxide substrate will attach to the active site of the enzyme to react with the ion of hydroxide. The zinc-bound OH-  attacks the carbon of CO2  therefore converting it into a bicarbonate ion. This occurs since the zinc ion has the +2 charge, which attracts the oxygen of water. It then deprotonates the water, thus, converting it into a better nucleophile so that the newly converted hydroxyl ion can attack the carbon dioxide. After the nucleophilic att ack of zinc bound OH-, addition of water molecule displaces the bicarbonate ion from the metal ion. The CA is then ready for another cycle of catalysis. (7) KINETICS OF REACTIONS CA inhibitors are class of pharmaceuticals that control the activity of carbonic anhydrase. It is inhibited by two classes of compounds, a metal complex forming anions and others are isosteres and sulfonamides. Inhibitors ionize upon binding with the enzyme to give way an NH- group that relocates the zinc hydroxide ions and shares a hydrogen bond. There are roughly 25 clinically used CA inhibitors as a drugs. It is mainly established as antiglaucoma drugs, diuretics, hypotensive agents, anticonvulsants, anticancer agents, antiepileptics, with additional use in the management of duodenal and gastric ulcers, osteoporosis and neurological disorder. (8) Acetazolamide Methazolamide Dorzolamide Topiramate Figure 3. Illustrations of some CA inhibitors (9) Figure 3.0 shows some CA inhibitors like Acetozolamide which acts as a mild diuretic. It cures glaucoma, altitude sickness, and some benign intracranial hypertension. Methazolamide treats glaucoma present in dogs which is called Open-angle glaucoma. While Topiramate which is a weak inhibitor, alleviate epilepsy, lennox gastuat syndrome and migraine headaches. And another CA inhibitor is the, Dorzolamide or sulphonamide which treat ocular hypertension or open-angele glaucoma. (10) CA activator regulates the proton transfer processes between the active site and the solvent system. It also binds at the entrance of the enzyme of the active site. One of the strong activator of CA is Histidine. Some amines and amino acids like l-Trp (tryptophan), l-Phe (Phenylalanine),  d-DOPA (D- 3,4-dihydroxyphenylalanine),  l-Tyr (Tyrosine), 4-amino-l-Phe also works as activators of CA. These CA activators are potentially target for drug development that can be useful as a derivative for the enhancement of synaptic efficacy which can be able to treat various conditions like, depression, alzheimers disease, ageing, spatial learning and memory therapy enhancer. (11) MODE OF REGULATION: Acetazolamide Inhibitor In case of excessive contents of CA in blood and peripheral areas of the lungs, proper regulation and inhibition is needed. Acetazolamide is a non competitive inhibitor that is effective in giving control with the catalytic reaction of the enzyme. This chemical complex substance is medically used o treat different conditions of moderate up to severe metabolic or respiratory alkalosis. Alkalosis may happen if excess CA is being reacted with the bicarbonate and carbon dioxide ions in the RBC, causing extreme absorption of bicarbonate thus giving the erythrocyte more basicity rather than having enough and sufficient pH level. Acetazolamide action is explained by interfering with bicarbonate (HCO3-) reabsorption in the kidneys, thereby giving enough acidity in the RBC, and further results to alkalinizing the urine. The action of inhibition results further to decreased synthesis of aqueous humor of the eye and causes the lowering of intraocular pressure. The interaction of Acetazolamide with CA does not occur with the active site, only close or remote to the active site. The net effect of this inhibitor basically changes the shape of CA that obviously leads to the inability of the substrate to bind properly, results to no catalytic reaction. (12) CARBONIC ANHYDRASE IN HEALTH AND DISEASE: Carbonic Anhydrase is found in numerous places in the body, including in the cerebro-spinal fluid, cytosol of some cells and mainly in the red blood cells. Since CA generates and utilizes protons and bicarbonate ions, it plays a major key role in the fluid balance and regulatory of pH in different parts of the body. Absence or mutation of the CA enzyme may lead to several diseases.  Also, CA inhibitor contributes to several treatments of diseases. One of the linked diseases of CA is the Osteopetrosis with cerebral calcification and renal acidosis. It is a syndrome deficient with CA in the body commonly called as Marble brain disease. This happens because sulfonamide inhibitor of CA can produce metabolic acidosis and have shown that CA inhibitors blocks the parathyroid hormone-induced the release of calcium bone which causes bone resorption. And since CA is present in the brain and CA inhibitors inhibits the production of cerebral spinal fluid, mutation of CA lead to cerebral calcification. Other disease associated with the deficiency of specific type of CAIII is the Myastenia gravis. It is an autoimmune neuromuscular disorder that results to a weak muscle of a person. Defects in CA IV can cause retinitis pigmentosa, a degeneration of retinal photoreceptor, which a patient experiences night vision blindness and loss of midperipheral visual. (13) Glaucoma, a condition wherein a build up of fluid in the eyes occurs and this presses the optic nerve that caused damage, is treated with the use of CA inhibitors like acetazolamide, brinzolamide, dorzolamide, and methazolamide. These inhibitors lessen the amount of fluid in the eye rapidly by 40% to 60% thus lowering the pressure inside the eye of a person with glaucoma. It now lessens the risk of optic nerve damage which promote vision loss. But prolong use of this drug affects the same enzyme in the tissue and may lead to kidney and liver damage The CA also plays an important role in the secretion of acid through the catalyzed hydration of excreted CO2 in the stomach lining which is mainly responsible in digestion of food. It helps to make pancreatic juice alkaline and our saliva neutral. In summary, CA performs different role and functions at their specific locations. (14)